Clinical Chemistry, Vol 29, 1396-1398, Copyright © 1983 by American Association for Clinical Chemistry

Variations of 1-deoxyglucose(1,5-anhydroglucitol) content in plasma from patients with insulin-dependent diabetes mellitus

S Yoshioka, S Saitoh, C Negishi, T Fujisawa, A Fujimori, O Takatani, M Imura and M Funabashi

The concentration of 1-deoxyglucose(1,5-anhydroglucitol) in plasma from patients with insulin-dependent diabetes mellitus was measured by gas- liquid chromatography with an all-glass capillary column. Twenty-one plasma samples were obtained from 21 patients before insulin therapy, and 34 more from 13 patients receiving insulin therapy. 1-Deoxyglucose was generally not detectable in plasmas of diabetic patients before they received insulin; it was measurable in the patients who had received insulin, although its concentration was low compared with that of healthy subjects. We therefore suggest that the absence of 1- deoxyglucose in plasma is one of the markers of metabolic states of diabetes, perhaps reflecting a disturbed function of carbohydrate metabolism; its presence in plasma within a normal range may reflect the better control of diabetic patients.

The following articles in journals at HighWire Press have cited this article:

				J. B. McGill, T. G. Cole, W. Nowatzke, S. Houghton, E. B. Ammirati, T. Gautille, and M. J. Sarno Circulating 1,5-Anhydroglucitol Levels in Adult Patients With Diabetes Reflect Longitudinal Changes of Glycemia: A U.S. trial of the GlycoMark assay Diabetes Care, August 1, 2004; 27(8): 1859 - 1865. [Abstract] [Full Text] [PDF]

				D. Stickle and J. Turk A kinetic mass balance model for 1,5-anhydroglucitol: applications to monitoring of glycemic control Am J Physiol Endocrinol Metab, October 1, 1997; 273(4): E821 - E830. [Abstract] [Full Text] [PDF]