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Clinical Chemistry 29: 1549-1550, 1983;
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Clinical Chemistry, Vol 29, 1549-1550, Copyright © 1983 by American Association for Clinical Chemistry

High creatine kinase MB isoenzyme activity associated with a rhabdomyosarcoma

PE Hickman, S Messina, JM Trotter and JR Masarei

A 20-year-old man was found to have high plasma creatine kinase (EC 2.7.3.2) activity in association with a rhabdomyosarcoma of the prostate. There was a very high proportion of the MB isoenzyme. Clinical findings and changes in creatine kinase activity with time showed that this increase was not ascribable to myocardial disease. We believe that the high proportion of CK-MB, confirmed by a combination of electrophoretic and immunoinhibition studies, originated from the tumor.


The following articles in journals at HighWire Press have cited this article:


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 Clin. Chem.Home page
S. Agewall
Increases of Creatine Kinase MB and Cardiac Troponin T in Serum of a Patient with Uterine Leiomyosarcoma
Clin. Chem., December 1, 2000; 46(12): 2016 - 2017.
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P. A. Isotalo, D. C. Greenway, and J. G. Donnelly
Metastatic Alveolar Rhabdomyosarcoma with Increased Serum Creatine Kinase MB and Cardiac Troponin T and Normal Cardiac Troponin I
Clin. Chem., September 1, 1999; 45(9): 1576 - 1578.
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Copyright © 1983 by the American Association for Clinical Chemistry.