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Clinical Chemistry 29: 1678-1682, 1983;
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Clinical Chemistry, Vol 29, 1678-1682, Copyright © 1983 by American Association for Clinical Chemistry

Optical fiber fluoroprobes in clinical analysis

MJ Sepaniak, BJ Tromberg and JF Eastham

We used quartz optical fibers and laser excitation in developing single- fiber fluoroprobes, to be used to measure molecular fluorescence in minute volumes of body fluids. We illustrate and discuss the analytical capabilities of these fluoroprobes. Limits of detection for the anti- tumor drug doxorubicin are about 10(-7) mol/L, by either conventional fluorescence or sequentially excited fluoroscence modes of detection. We also report the results of preliminary in vivo measurements of doxorubicin in the interstitial fluids of human tumors, heterotransplanted in immune-deficient laboratory mice.


The following articles in journals at HighWire Press have cited this article:


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 Transactions of the Institute of Measurement and ControlHome page
A.J. Guthrie, R. Narayanaswamy, and D.A. Russell
Optical fibres in chemical sensing - a review
Transactions of the Institute of Measurement and Control, April 1, 1987; 9(2): 71 - 80.
[Abstract] [PDF]

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 ScienceHome page
J. Peterson and G. Vurek
Fiber-optic sensors for biomedical applications
Science, April 13, 1984; 224(4645): 123 - 127.
[Abstract] [PDF]


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Copyright © 1983 by the American Association for Clinical Chemistry.