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Clinical Chemistry 3: 37-48, 1957;
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Clinical Chemistry, Vol 3, 37-48, Copyright © 1957 by the American Association for Clinical Chemistry

Measurement of the Electrical Conductivity of Sweat

Its Application to the Study of Cystic Fibrosis of the Pancreas

Truman S. Licht 1, Milton Stern 1, and Harry Shwachman 1

1 Department of Chemistry, Boston College (T. S. L., M. S.); the Division of Laboratories and Research of the Children's Medical Center (M. S., H. S.); and the Department of Pediatrics, Harvard Medical School (H. S.), Boston, Mass.

1. A method has been described for the measurement of the electrical conductivity of thermally induced sweat.

2. Conductivity data of sweat samples collected from 124 children ranging in ages from 4 weeks to 16 years is presented. Forty-seven patients have cystic fibrosis of the pancreas and exhibit a mean value for the sweat conductivity of 16,150 micromhos/cm. In the remaining 77 subjects, of which 6 were healthy and the others had miscellaneous illnesses, the mean value for the sweat conductivity is 5,560 micromhos/cm. All of the subjects with sweat conductivities less than 9000 micromhos/cm. did not have cystic fibrosis; all of the subjects with sweat conductivities greater than 12,000 micromhos/cm., with one exception, had cystic fibrosis. The intermediate range (9000 to 12,000 micromhos/cm.) comprised less than 10 per cent of the subjects studied. It has been shown that measurement of chloride and/or sodium concentration in sweat is a more reliable diagnostic index of cystic fibrosis of the pancreas.

Submitted on June 8, 1956




The following articles in journals at HighWire Press have cited this article:


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P. M. Quinton
Cystic Fibrosis: Lessons from the Sweat Gland
Physiology, June 1, 2007; 22(3): 212 - 225.
[Abstract] [Full Text] [PDF]

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R. Rej
Clinical Chemistry through Clinical Chemistry: A Journal Timeline
Clin. Chem., December 1, 2004; 50(12): 2415 - 2458.
[Abstract] [Full Text] [PDF]


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Copyright © 1957 by the American Association for Clinical Chemistry.