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Clinical Chemistry 3: 125-134, 1957;
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Clinical Chemistry, Vol 3, 125-134, Copyright © 1957 by the American Association for Clinical Chemistry

Chemical Findings in Patients with Acute Nonfatal Barbiturate Intoxication

Irving Sunshine 1 and Earl Hackett 1

1 Departments of Pharmacology and Pathology, School of Medicine, Western Reserve University, Cleveland, Ohio, and the Cuyahoga County Coroner's Office.

1. Clinical and chemical data on acutely intoxicated patients show a direct quantitative relationship of the patient's blood barbiturate levels to his clinical condition.

2. The "half-life" of phenobarbital, amobarbital, and pentobarbital was determined to aid in prognosis of an intoxicated patient with a given blood barbiturate level.

3. Urinary clearance studies showed that the clearance was directly proportional to the urine flow.

4. A patient's urine barbiturate level has no relation to his clinical condition.

Submitted on January 10, 1957






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Copyright © 1957 by the American Association for Clinical Chemistry.