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Clinical Chemistry 3: 599-608, 1957;
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Clinical Chemistry, Vol 3, 599-608, Copyright © 1957 by the American Association for Clinical Chemistry

"U" Protein and Migration Ratios in Paper Electrophoresis

Joel R. Stern 1, Roland F. Mais 1, and Joseph D. Boggs 1

1 Department of Pathology, Children's Memorial Hospital, Chicago, Ill.

Paper electrophoresis of serum from children with liver and kidney disease has led to recognition of a protein which migrates between the 2 and globulins. This protein has been observed by other workers, but because of confusion in nomenclature, a new designation, "U" protein, has been employed. The use of migration ratios in locating peaks of the 2 "U" protein, and globulin when these components resolve poorly has been discussed.

Characterization of "U" protein by employing the periodic acid-reduced fuchsin test for carbohydrate-protein complexes and Sudan black B for lipoprotein showed: (1)"U" protein varies in its content of protein-carbohydrate complex, and (2)"U" protein may be lipo-protein. Evidence based on benzidine tests and intentional hemolysis indicated that "U" protein was not an artifact resulting from accidental hemolysis, but a protein which is found in serum under certain physiological conditions.

Submitted on March 21, 1957






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Copyright © 1957 by the American Association for Clinical Chemistry.