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Clinical Chemistry 3: 646-656, 1957;
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Clinical Chemistry, Vol 3, 646-656, Copyright © 1957 by the American Association for Clinical Chemistry

Determination of Ketone Bodies in Blood and Urine by Means of Vanillin in Alkaline Medium

Victor E. Levine 1 and Michael Taterka 1

1 Abbott Laboratories, North Chicago, Ill.

Abbott Laboratories, North Chicago, III

Vanillin in an alkaline reaction mixture is a very sensitive reagent for acetone and diacetic acid. A qualitative and a quantitative method have been developed for the acetone bodies in blood and in urine by means of a vanillin-alkali reagent. Acetone and diacetic acid are distilled off and caught in a sodium bisulfite solution, which is allowed to react with vanillin in alkaline medium to form a color complex, which is measured spectrophotometrically.

Vanillin has many advantages over the salicylaldehyde method of Behre. These have been enumerated in the text.

Submitted on March 24, 1957






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Copyright © 1957 by the American Association for Clinical Chemistry.