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Clinical Chemistry 3: 663-684, 1957;
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Clinical Chemistry, Vol 3, 663-684, Copyright © 1957 by the American Association for Clinical Chemistry

Influence of Variations in Body-Fluid Volumes on Sodium Metabolism in Man

Berth Josephson 1

1 Clinical Laboratory, St. Erik 's Hospital, Stockholm, Sweden.

A review has been given of recent papers on the influence of acute changes in extracellular, extravascular fluid volume and in plasma volume on the salt metabolism. The influence of intravascular pressure, pitressin, adrenal steroids, etc., has been mentioned. Some work from the author's laboratory has been reported. It was found in this laboratory that a large intravenous infusion-25 ml./min. during 1-2 hours-of iso-oncotic glucose has no influence on sodium excretion in normal man, but that it gives rise to a very high increase of the sodium output in cases of arterial hypertension. Later on it was found that patients with cardiac failure behave as the hypertensive do in this respect. On the other hand, an intravenous infusion of a corresponding amount of iso-oncotic dextran solution gives a considerable decrease of sodium excretion in healthy subjects as well as in patients with the above-mentioned diseases. The correlation between these results and the changes of the kidney function and the renal hemodynamic have been discussed.






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Copyright © 1957 by the American Association for Clinical Chemistry.