Clinical Chemistry, Vol 30, 1607-1610, Copyright © 1984 by American Association for Clinical Chemistry

Interpreting the profile of liver-function tests in pediatric liver transplants

R Simonsen and MA Virji

Results of traditional laboratory tests of liver function were correlated with the clinical course in 26 pediatric patients after liver transplantation. On the basis of clinical outcome after transplantation, the patients were divided into two groups: (a) uncomplicated course with short hospital stay, and (b) post- transplantation course complicated by multiple clinical problems. The patterns of results for tests reflecting liver function--bilirubin (total and conjugated), aspartate (EC 2.6.1.1) and alanine (EC 2.6.1.2) aminotransferases, and gamma-glutamyltransferase (gamma GT, EC 2.3.2.2)- -were consistent with the clinical findings in these patients. Values for alkaline phosphatase (EC 3.1.3.1), however, were only rarely increased, even when there was clinical evidence of biliary obstruction. Not only was serum gamma GT increased in obstructive jaundice, but this sometimes was the only test giving results outside the normal limits. We suggest that the persistent and marked increases of gamma GT observed in half of the patients may have resulted from immune-mediated damage to the transplanted liver.

The following articles in journals at HighWire Press have cited this article:

				P. E. Hickman, J. M. Potter, and A. J. Pesce Clinical chemistry and post-liver-transplant monitoring Clin. Chem., August 1, 1997; 43(8): 1546 - 1554. [Abstract] [Full Text] [PDF]