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Clinical Chemistry 30: 1631-1636, 1984;
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Clinical Chemistry, Vol 30, 1631-1636, Copyright © 1984 by American Association for Clinical Chemistry

Urinary excretion of acetaminophen and its metabolites as studied by proton NMR spectroscopy

JR Bales, PJ Sadler, JK Nicholson and JA Timbrell

Acetaminophen and its glucuronide, sulfate, N-acetyl-L-cysteinyl, and L- cysteinyl metabolites can be rapidly detected by 1H NMR spectroscopy of intact, untreated human urine. Study of the time course of excretion of these metabolites in five clinically normal men after ingestion of the usual 1-g therapeutic dose of the drug showed that the mean 24-h excretion of the drug and these metabolites as determined by NMR was 77.3% of the dose. Respective relative proportions of the above metabolites were 49.9%, 37.6%, 3.0%, and 9.5% (L-cysteinyl plus free drug). Excretion of some other metabolites in urine, including creatinine, citrate, hippurate, and sarcosine was measured concurrently. Excretion of creatinine and sarcosine was closely correlated.


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Copyright © 1984 by the American Association for Clinical Chemistry.