Clinical Chemistry
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Clinical Chemistry 30: 1861-1863, 1984;
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Clinical Chemistry, Vol 30, 1861-1863, Copyright © 1984 by American Association for Clinical Chemistry

Reactivation of serum creatine kinase isoenzyme BB in patients with malignancies

LB Abbott and JA Lott

Reactivation of serum creatine kinase isoenzyme BB (CK-BB) with 2- mercaptoethanol and EDTA increased the electrophoretic detection rate of CK-BB from 34% to 78% in 58 hospitalized patients with various malignancies. Patients with solid tumors showed the largest and patients with hematologic malignancies the smallest percentage increase in CK-BB after reactivation. For serum from 50 hospitalized patients without cancer, reactivation resulted in detectable CK-BB in two patients; the CK-BB band was never seen in 15 healthy adults. For reasons unknown, five of eight patients with senile dementia of the Alzheimer's type showed CK-BB in serum after reactivation, as did two of five patients suspected of having this disorder. Serum CK-BB may be a useful tumor marker if reactivation with a thiol and EDTA is used immediately after collection.




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Copyright © 1984 by the American Association for Clinical Chemistry.