Clinical Chemistry
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Clinical Chemistry 30: 188-191, 1984;
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Clinical Chemistry, Vol 30, 188-191, Copyright © 1984 by American Association for Clinical Chemistry

Concentrations of non-glucose polyols in serum and cerebrospinal fluid from apparently healthy adults and children

S Yoshioka, S Saitoh, S Seki and K Seki

Six non-glucose polyols--mannose, fructose, 1-deoxyglucose, mannitol, glucitol, and inositol--were identified and evaluated in human serum and cerebrospinal fluid by gas-liquid chromatography and by gas-liquid chromatography/mass spectrometry. Concentrations of fructose, mannose, and inositol in the serum of healthy persons or children without metabolic diseases varied with age, as already reported for 1- deoxyglucose. Fructose, inositol, and glucitol concentrations in cerebrospinal fluid significantly exceeded those in serum. The method described here for determining polyols and for evaluating polyol patterns in serum, as well as the resulting data on children and healthy subjects, should be useful in investigations of the clinical and physiological significance of polyols.




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Copyright © 1984 by the American Association for Clinical Chemistry.