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Clinical Chemistry 30: 437-439, 1984;
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Clinical Chemistry, Vol 30, 437-439, Copyright © 1984 by American Association for Clinical Chemistry

A thyrotropin radioimmunoassay kit evaluated vs two reference assays

ST Bigos, AE Pekary, J MacLean, CE Pierce, AW Reed and JM Hershman

We evaluated a double-antibody radioimmunoassay kit for thyrotropin that includes calibrators prepared in a matrix of human serum and involves overnight nonequilibrium. Results were compared with those from two reference assays for thyrotropin. The range of within-assay CVs for the kit for thyrotropin values between 0.9 and 2.4 milli-int. units/L was 2.2 to 5.3%, that for between-assay CVs was 8.3 to 30%. The estimated minimum detectable concentration of thyrotropin was 0.6 milli- int. unit/L. We saw no cross reactivity with human choriogonadotropin by any of 48 sera from pregnant women. The original lot of serum specified as thyrotropin-free contained small but measurable amounts of thyrotropin; a second lot did not. Clinical data generated with the kit and the reference assays correlated well and were consistent with the clinical status of various categories of patients.




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Copyright © 1984 by the American Association for Clinical Chemistry.