Clinical Chemistry
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Clinical Chemistry 30: 741-742, 1984;
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Clinical Chemistry, Vol 30, 741-742, Copyright © 1984 by American Association for Clinical Chemistry

Screening for macroamylase in a community hospital

CA Isham, NA Ridgeway, R Hedrick and JC Cate 4th

We evaluated the polyethylene glycol precipitation test (Gastroenterology 83: 378-382, 1982), looking for macroamylase in the serum of 66 patients whose values for serum amylase were above normal. Three patients (4.5%) were identified by this method as having macroamylase , and this was confirmed by gel-filtration chromatography and electrophoresis. We find this to be the test of choice as a screening procedure for macroamylasemia because of its speed, simplicity, and apparent reliability. Diagnosis of macroamylasemia is important in preventing needless treatment and investigation for pancreatitis.




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Copyright © 1984 by the American Association for Clinical Chemistry.