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Clinical Chemistry 30: 763-768, 1984;
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Clinical Chemistry, Vol 30, 763-768, Copyright © 1984 by American Association for Clinical Chemistry

Ultrastructural localization of aluminum in patients with dialysis- associated osteomalacia

AH Verbueken, FL Van de Vyver, RE Van Grieken, GJ Paulus, WJ Visser, P D'Haese and ME De Broe

Using laser microprobe mass analysis, we studied the ultrastructural localization of aluminum in liver and bone tissue of chronic- hemodialysis patients with proven aluminum-induced osteomalacia. In the liver, aluminum was observed to be almost exclusively associated with iron. Detectable aluminum and large amounts of iron were found in lysosomes of both hepatocytes and Kupffer cells. In bone, aluminum was localized at the osteoid/calcified-bone interface and also was associated with iron in some cases.




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Copyright © 1984 by the American Association for Clinical Chemistry.