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Clinical Chemistry 30: 768-773, 1984;
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Clinical Chemistry, Vol 30, 768-773, Copyright © 1984 by American Association for Clinical Chemistry

Fluoroimmunoassays for procainamide and N-acetylprocainamide compared with a liquid-chromatographic method

JJ MacKichan, JD Coyle, BJ Shields, H Boudoulas and JJ Lima

We measured procainamide and its active metabolite, N- acetylprocainamide (NAPA), in 80 sera from 37 patients by a new fluorimmunoassay procedure and an established "high-performance" liquid- chromatographic method. Additive and proportional differences between the methods were 0.07 mg/L and 9%, respectively, for procainamide and 0.62 mg/L and 16% for NAPA. Between-day CVs by the chromatographic and immunoassay methods, respectively, were 3.9% and 2.2% for procainamide at a concentration of 6 mg/L, and 5.1% and 1.2% for NAPA (14 mg/L). We applied a modification of the fluoroimmunoassay for determination of procainamide concentrations, using sera obtained during a pharmacokinetic study, and demonstrated excellent agreement with the chromatographic method.




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Copyright © 1984 by the American Association for Clinical Chemistry.