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Clinical Chemistry 30: 914-916, 1984;
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Clinical Chemistry, Vol 30, 914-916, Copyright © 1984 by American Association for Clinical Chemistry

Hyperviscosity caused by hyaluronic acid in serum in a case of Wilms' tumor

AH Wu, OS Parker and L Ford

We describe the case of a three-year-old girl with Wilms' tumor, whose serum showed at least a fivefold increase in relative viscosity although concentrations of albumin and immunoglobulins were normal. An unusual electrophoretogram of serum protein prompted further investigation. The increased viscosity was caused by the presence of high concentrations of hyaluronic acid, a glycosaminoglycan normally not detectable in serum.


The following articles in journals at HighWire Press have cited this article:


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 CLIN APPL THROMB HEMOSTHome page
J. J. Michiels, W. Schroyens, Z. Bememan, and M. van der Planken
Atypical Variant of Acquired von Willebrand Syndrome in Wilms Tumor: Is Hyaluronic Acid Secreted by Nephroblastoma Cells the Cause?
Clinical and Applied Thrombosis/Hemostasis, April 1, 2001; 7(2): 102 - 105.
[Abstract] [PDF]


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