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Clinical Chemistry, Vol 30, 1477-1488, Copyright © 1984 by American Association for Clinical Chemistry
WR Matson, P Langlais, L Volicer, PH Gamache, E Bird and KA Mark
Coulometric electrodes in series have been used with liquid chromatography with electrochemical detection to increase selectivity and resolution for the direct analysis of tissue neurotransmitters. Use of three coulometric sensors for electrochemical modification, selectivity, and peak identification has been expanded into "gate" cells of three or four coulometric electrodes that allow elimination of all electrochemically irreversible substances, and "array" cells of up to 15 coulometric electrodes for separation of co-eluting compounds by their current/voltage characteristics. On-column sensitivity of the sensor arrays is 0.4 to 4 pg. Gate cell selectivity favors electrochemically reversible compounds over irreversible ones, e.g., 3- methoxy-4-hydroxyphenylglycol vs ascorbate, by a factor of up to 10(4). Resolution across the multi-electrode array cells allows separation of co-eluting compounds with half-wave potentials differing by as little as 30 to 40 mV. Cells with three to 15 electrodes have been used to measure monoamines and metabolites in brain; monoamines directly in serum filtrate; and the state of oxidation of 5-hydroxytryptamine and 5- hydroxytryptophan in cerebrospinal fluid of patients with Alzheimer's disease.
The following articles in journals at HighWire Press have cited this article:
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H. Shi, K. E. Vigneau-Callahan, A. I. Shestopalov, P. E. Milbury, W. R. Matson, and B. S. Kristal Characterization of Diet-Dependent Metabolic Serotypes: Primary Validation of Male and Female Serotypes in Independent Cohorts of Rats J. Nutr., May 1, 2002; 132(5): 1039 - 1046. [Abstract] [Full Text] [PDF]
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K. E. Vigneau-Callahan, A. I. Shestopalov, P. E. Milbury, W. R. Matson, and B. S. Kristal Characterization of Diet-Dependent Metabolic Serotypes: Analytical and Biological Variability Issues in Rats J. Nutr., March 1, 2001; 131(3): 924S - 932. [Abstract] [Full Text]
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 Y. Takeuchi, H. Matsushita, H. Sakai, H. Kawano, and M. Ochi Developmental Changes in Cerebrospinal Fluid Concentrations of Monoamine-Related Substances in Patients With Dentatorubral-Pallidoluysian Atrophy J Child Neurol, February 1, 2001; 16(2): 79 - 82. [Abstract] [PDF]
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R. D. Hoeldtke, K. D. Bryner, G. G. Horvath, R. W. Phares, L. F. Broy, and G. R. Hobbs Redistribution of Sudomotor Responses Is an Early Sign of Sympathetic Dysfunction in Type 1 Diabetes Diabetes, February 1, 2001; 50(2): 436 - 443. [Abstract] [Full Text]
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Y. Takeuchi, H. Matsushita, H. Sakai, H. Kawano, K. Yoshimoto, and T. Sawada Developmental Changes in Cerebrospinal Fluid Concentrations of Monoamine-Related Substances Revealed With a Coulochem Electrode Array System J Child Neurol, April 1, 2000; 15(4): 267 - 270. [Abstract] [PDF]
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 R. D. Hoeldtke, K. D. Bryner, P. Komanduri, I. Christie, G. Ganser, and G. R. Hobbs Decreased Prorenin Processing Develops before Autonomic Dysfunction in Type 1 Diabetes J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 585 - 589. [Abstract] [Full Text]
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 L. C. Goudas, A. Langlade, A. Serrie, W. Matson, P. Milbury, C. Thurel, P. Sandouk, and D. B. Carr Acute Decreases in Cerebrospinal Fluid Glutathione Levels after Intracerebroventricular Morphine for Cancer Pain Anesth. Analg., November 1, 1999; 89(5): 1209 - 1209. [Abstract] [Full Text] [PDF]
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 P. J. Blanchet, J. Fang, K. Hyland, L. A. Arnold, M. M. Mouradian, and T. N. Chase Short-term effects of high-dose 17{beta}-estradiol in postmenopausal PD patients: A crossover study Neurology, July 1, 1999; 53(1): 91 - 91. [Abstract] [Full Text]
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R. D. Hoeldtke, G. G. Horvath, K. D. Bryner, and G. R. Hobbs Treatment of Orthostatic Hypotension with Midodrine and Octreotide J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 339 - 343. [Abstract] [Full Text]
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 L. Volicer, P. J. Langlais, W. R. Matson, K. A. Mark, and P. H. Gamache Serotoninergic System in Dementia of the Alzheimer Type: Abnormal Forms of 5-Hydroxytryptophan and Serotonin in Cerebrospinal Fluid Arch Neurol, December 1, 1985; 42(12): 1158 - 1161. [Abstract] [PDF]
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L. Volicer, L. K. Direnfeld, M. Freedman, M. L. Albert, P. J. Langlais, and E. D. Bird Serotonin and 5-Hydroxyindoleacetic Acid in CSF: Difference in Parkinson's Disease and Dementia of the Alzheimer's Type Arch Neurol, February 1, 1985; 42(2): 127 - 129. [Abstract] [PDF]
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