Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 31: 1743-1748, 1985;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mifflin, T. E.
Right arrow Articles by Herold, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mifflin, T. E.
Right arrow Articles by Herold, D. A.

Clinical Chemistry, Vol 31, 1743-1748, Copyright © 1985 by American Association for Clinical Chemistry

University of Virginia case conference. Macroamylase, macro creatine kinase, and other macroenzymes

TE Mifflin, DE Bruns, U Wrotnoski, RH MacMillan, RG Stallings, RA Felder and DA Herold

The importance of macroenzymes has become increasingly apparent in recent years (1,2). Macroamylase (EC 3.2.1.1) and macro CK (EC 2.7.3.2) are the macroenzymes most commonly noted in the clinical laboratory, and they are frequently responsible for diagnostic confusion. Several methods are available for the confirmation and analysis of macroenzymes, many of which require expensive equipment or complicated techniques. In this report we summarize two cases of macro creatine kinase and two cases of macroamylase that illustrate the clinical importance of recognizing these macroenzymes. We review the features of these macroenzymes, discuss their laboratory evaluation, and describe a simple method that we have used to detect the macroenzymes in these (and other) patients at our institution. Finally, we review the literature on other, less commonly observed macroenzymes in human blood. We stress (a) the impact of methodology on clinical impressions and (b) the importance of discussing laboratory observations with the patient's physician and communicating them to the patient's medical record in writing.


The following articles in journals at HighWire Press have cited this article:


Home page
 Rheumatology (Oxford)Home page
B. Galarraga, D. Sinclair, M. N. Fahie-Wilson, F. C. McCrae, R. G. Hull, and J. M. Ledingham
A rare but important cause for a raised serum creatine kinase concentration: two case reports and a literature review
Rheumatology, January 1, 2003; 42(1): 186 - 188.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
Y. E. Taes, H. Louagie, J.-P. Yvergneaux, M. L. De Buyzere, H. De Puydt, J. R. Delanghe, and J. A. Lott
Prolonged Hyperlipasemia Attributable to a Novel Type of Macrolipase
Clin. Chem., December 1, 2000; 46(12): 2008 - 2013.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
D. R. Dufour, J. A. Lott, F. S. Nolte, D. R. Gretch, R. S. Koff, and L. B. Seeff
Diagnosis and Monitoring of Hepatic Injury. I. Performance Characteristics of Laboratory Tests
Clin. Chem., December 1, 2000; 46(12): 2027 - 2049.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the American Association for Clinical Chemistry.