Clinical Chemistry
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Clinical Chemistry 31: 1820-1823, 1985;
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Clinical Chemistry, Vol 31, 1820-1823, Copyright © 1985 by American Association for Clinical Chemistry

Particle-counting immunoassay of a fetuin-like antigen in serum and cerebrospinal fluid

OC Fagnart, CL Cambiaso, CJ Sindic and PL Masson

A fetuin-like antigen was detected (smallest concentration detectable: 5 micrograms/L) by particle-counting immunoassay in 2% (13/641) of consecutive patients' sera but not in sera from 80 healthy blood donors, 40 neonates, or 40 pregnant women. The relation of the presence of detectable antigen to patients' diagnosis is not yet clear. However, in the group with cancer (154), it was found only in two of four patients with nephroblastoma and in three of five with tumors of tissue derived from the neurological crest: retinoblastoma (1/1), neuroblastoma (1/3), and medulloblastoma (1/1). Serum specimens from 422 patients with neurological disorders showed the antigen at a concentration greater than 5 micrograms/L in cases of neurosyphilis (5/11), peripheral neuropathy (12/38), Guillain-Barre syndrome (7/27), and multiple sclerosis (74/184). When we assayed 232 specimens of cerebrospinal fluid from the same neurological patients, we found the antigen in two cases of multiple sclerosis (6 and 15 micrograms/L) and in one case of Guillain-Barre syndrome (54 micrograms/L).




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Copyright © 1985 by the American Association for Clinical Chemistry.