Clinical Chemistry
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Clinical Chemistry 31: 1838-1840, 1985;
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Clinical Chemistry, Vol 31, 1838-1840, Copyright © 1985 by American Association for Clinical Chemistry

Value of measuring C-terminal parathyrin in differential diagnosis of hypercalcemia

DP Scott, PR Teasdale and R Swaminathan

We measured calcium, phosphate, chloride, albumin, C-terminal parathyrin, and beta 2-microglobulin in serum from 102 hypercalcemic patients: 42 with primary hyperparathyroidism and 60 with neoplasia. The calcium concentrations and the discriminant function index of Johnson et al. (Clin Chem 28, 333-338, 1982) were higher in malignant hypercalcemia than in primary hyperparathyroidism. The diagnostic efficiency of the index and of parathyrin concentration was 82% and 78%, respectively. Using the ratio of parathyrin to beta 2- microglobulin increased the diagnostic efficiency to 98%; the ratio of the discriminant index to parathyrin concentration had a diagnostic efficiency of 100%. We conclude that C-terminal assay by itself is no better than the discriminant function index.




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Copyright © 1985 by the American Association for Clinical Chemistry.