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Clinical Chemistry 31: 1865-1867, 1985;
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Clinical Chemistry, Vol 31, 1865-1867, Copyright © 1985 by American Association for Clinical Chemistry

Thyrotropin as measured by a sensitive immunoradiometric assay

JH McBride, RV Thibeault and DO Rodgerson

An immunoradiometric assay (Boots-Celltech's "Sucrosep"; IRMA) for thyrotropin (TSH) was evaluated and results were compared with those of our in-house RIA procedure. The IRMA had a sensitivity of 0.02 milli- int. unit/L. In addition it displayed excellent intra- and inter-batch precision, cross-reacted negligibly with other pituitary hormones, and appeared to be relatively free of matrix effects (although deionized water did give an apparent TSH concentration of 0.13 milli-int. unit/L). Over the range 1.2 to 64 milli-int. units/L, correlation between the IRMA (y) and RIA (x) was excellent: y = 1.16x - 1.69 (r = 0.98). The normal reference interval for the IRMA was 0.4 to 4.2 milli- int. units/L. For patients suspected of hyperthyroidism who had been subjected to the thyroliberin test, the IRMA more effectively differentiated between euthyroidism and hyperthyroidism. During testing with thyroliberin, all nonresponding hyperthyroid patients had initial baseline TSH concentrations of less than 0.02 milli-int. unit/L by IRMA. This sensitive assay represents an important advance in the ability to differentiate between euthyroidism and hyperthyroidism.


The following articles in journals at HighWire Press have cited this article:


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 Arch Intern MedHome page
C. T. Sawin, A. Geller, M. M. Kaplan, P. Bacharach, P. W. F. Wilson, and J. M. Hershman
Low Serum Thyrotropin (Thyroid-Stimulating Hormone) in Older Persons Without Hyperthyroidism
Arch Intern Med, January 1, 1991; 151(1): 165 - 168.
[Abstract] [PDF]

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 ANN INTERN MEDHome page
M. Helfand and L. M. Crapo
Monitoring Therapy in Patients Taking Levothyroxine
Ann Intern Med, September 15, 1990; 113(6): 450 - 454.
[Abstract] [PDF]

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 Arch Intern MedHome page
D. A. Ehrmann, M. Weinberg, and D. H. Same
Limitations to the Use of a Sensitive Assay for Serum Thyrotropin in the Assessment of Thyroid Status
Arch Intern Med, February 1, 1989; 149(2): 369 - 372.
[Abstract] [PDF]

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 ANN INTERN MEDHome page
D. A. Ehrmann and D. H. Sarne
Serum Thyrotropin and the Assessment of Thyroid Status
Ann Intern Med, February 1, 1989; 110(3): 179 - 181.
[Abstract] [PDF]


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