Clinical Chemistry Siemens Point of Care - Urinalysis
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Clinical Chemistry 31: 1900-1904, 1985;
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Clinical Chemistry, Vol 31, 1900-1904, Copyright © 1985 by American Association for Clinical Chemistry

Comparison of creatinine as determined with the Ames Seralyzer and by three Jaffe-based methods

MH Kroll, D Olson, M Rawe, C King, C Hagengruber and RJ Elin

We compared results for urinary creatinine, serum creatinine, and creatinine clearance, as determined with the Ames Seralyzer, with results determined with the Beckman ASTRA, the DuPont aca, and Technicon's AutoAnalyzer and SMAC. Results for urinary creatinine from the Seralyzer differed significantly (p less than 0.05) from those obtained with the ASTRA and AutoAnalyzer, but not with the aca. The Seralyzer results for serum creatinine were at least 1.0 mg/L higher (p less than 0.05) than by the other three methods. Results for creatinine clearance from the Seralyzer were 8 to 11 mL/min lower (p less than 0.05) than results by the other three methods. These differences are related to the positive interference by bilirubin in the Seralyzer creatinine method. We also evaluated 23 other compounds for interference with these methods for creatinine.




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Copyright © 1985 by the American Association for Clinical Chemistry.