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Clinical Chemistry 31: 2032-2035, 1985;
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Clinical Chemistry, Vol 31, 2032-2035, Copyright © 1985 by American Association for Clinical Chemistry

Plasma apolipoprotein pattern in fish-eye disease examined by high- resolution two-dimensional electrophoresis

T Marshall, KM Williams, L Holmquist, LA Carlson and O Vesterberg

We compared the plasma protein patterns of the two living patients suffering from fish-eye disease with those of appropriate controls, using high-resolution two-dimensional electrophoresis. Quantitative abnormalities were detected in plasma polypeptides corresponding to the isoforms of apolipoproteins A-I and A-II. The disease was characterized by normal concentrations of proapo A-I but dramatically subnormal concentrations of the other apo A-I isoforms and apo A-II. No significant difference was detected in the concentrations of other plasma proteins. These findings are discussed in relation to other apolipoprotein disorders.




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Copyright © 1985 by the American Association for Clinical Chemistry.