Clinical Chemistry
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Clinical Chemistry 31: 206-212, 1985;
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Clinical Chemistry, Vol 31, 206-212, Copyright © 1985 by American Association for Clinical Chemistry

Computer evaluation of statistical procedures, and a new quality- control statistical procedure

AS Blum

I describe a program for definitive comparison of different quality- control statistical procedures. A microcomputer simulates quality- control results generated by repetitive analytical runs. It applies various statistical rules to each result, tabulating rule breaks to evaluate rules as routinely applied by the analyst. The process repeats with increasing amounts of random and systematic error. Rate of false rejection and true error detection for currently popular statistical procedures were comparatively evaluated together with a new multirule procedure described here. The nature of the analyst's response to out- of-control signals was also evaluated. A single-rule protocol that is as effective as the multirule protocol of Westgard et al. (Clin Chem 27:493, 1981) is reported.





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Copyright © 1985 by the American Association for Clinical Chemistry.