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Clinical Chemistry 31: 235-238, 1985;
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Clinical Chemistry, Vol 31, 235-238, Copyright © 1985 by American Association for Clinical Chemistry

Phenylalanine analyses of blood-spot control materials: preparation of samples and evaluation of interlaboratory performance

FW Spierto, TL Hearn, FH Gardner and WH Hannon

Aliquots (0.1 mL) of whole-blood pools prepared to contain various concentrations of phenylalanine were applied to filter-paper collection cards, dried, and stored in sealed bags. We measured the phenylalanine content of the dried blood spots by bioassay, fluorometry, and "high- performance" liquid chromatography, and found that the concentrations remained constant for two years when samples were kept at -20 degrees C or lower. Intra- and interlaboratory studies showed that results for phenylalanine were greater for laboratories using bioassay procedures than for those using fluorometric procedures. Further, CVs (both among- and within-laboratory) obtained with fluorometric procedures were nearly half as great as the CVs obtained by laboratories using bioassay techniques.




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Copyright © 1985 by the American Association for Clinical Chemistry.