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Clinical Chemistry 31: 451-453, 1985;
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Clinical Chemistry, Vol 31, 451-453, Copyright © 1985 by American Association for Clinical Chemistry

An L-lactate sensor with immobilized enzyme for use in in vivo studies with an endocrine artificial pancreas

M Mascini, S Fortunati, D Moscone, G Palleschi, M Massi-Benedetti and P Fabietti

We report the features of a sensor for determining L-lactate. An oxygen sensor, coupled to a nylon net with chemically bound L-lactate oxidase (EC 1.1.3.2), is inserted into an artificial pancreas (Biostator, Miles) "downstream" from the glucose sensor. We used the sensor to continuously monitor the L-lactate concentration in blood after a "glucose clamp" experiment with a diabetic patient. L-Lactate determinations in blood drawn from the patient every 15 min agreed well with results obtained by use of the L-lactate sensor.


The following articles in journals at HighWire Press have cited this article:


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N. Hamamatsu, Y. Nomiya, T. Aita, M. Nakajima, Y. Husimi, and Y. Shibanaka
Directed evolution by accumulating tailored mutations: Thermostabilization of lactate oxidase with less trade-off with catalytic activity
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Copyright © 1985 by the American Association for Clinical Chemistry.