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Clinical Chemistry 31: 478-479, 1985;
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Clinical Chemistry, Vol 31, 478-479, Copyright © 1985 by American Association for Clinical Chemistry

An albumin dimer in urine

JP Beilby, C Chin, P Garcia-Webb and CI Bhagat

An albumin dimer (approximately 134 000 Da) was present, along with monomeric albumin, in freshly voided urine but not in serum from a 53- year-old man with alcoholic liver disease and chronic renal failure. The dimerization, evidently via disulfide bonds, resulted in a loss of [125I]thyroxin-binding capacity. This suggests that the S--S bridging is at a site different from that previously reported. The dimer was unstable at all storage temperatures studied.




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Copyright © 1985 by the American Association for Clinical Chemistry.