Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 31: 722-726, 1985;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harrington, M. G.
Right arrow Articles by Torrey, E. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harrington, M. G.
Right arrow Articles by Torrey, E. F.

Clinical Chemistry, Vol 31, 722-726, Copyright © 1985 by American Association for Clinical Chemistry

Differences in cerebrospinal fluid proteins between patients with schizophrenia and normal persons

MG Harrington, CR Merril and EF Torrey

A survey of cerebrospinal fluid (CSF) proteins from normal persons and patients with schizophrenia reveals differences between the two populations. Computer-assisted densitometry of 68 proteins, resolved by two-dimensional electrophoresis and made visible by silver staining, shows six changes. Compared with their occurrence in the normal group, two proteins are increased in the schizophrenic patients by 22% and 27%, while four proteins are decreased by 29%, 46%, 20%, and 37% (p less than 0.005). Furthermore, two additional 40 000-Da proteins are found in CSF from 31.5% of the schizophrenic patients. Although these disease-associated proteins have not yet been found in 12 other neurological and psychiatric conditions, they have been found in patients with herpes simplex encephalitis (90%), Creutzfeldt-Jakob disease (67%), multiple sclerosis (13%), Parkinson's disease (12%), and a single case of Guillain-Barre syndrome. These two 40 000-Da proteins have never been found in CSF from any of 99 normal persons.


The following articles in journals at HighWire Press have cited this article:


Home page
 Brief Funct Genomic ProteomicHome page
R. G. Biringer, H. Amato, M. G. Harrington, A. N. Fonteh, J. N. Riggins, and A. F. R. Huhmer
Enhanced sequence coverage of proteins in human cerebrospinal fluid using multiple enzymatic digestion and linear ion trap LC-MS/MS
Brief Funct Genomic Proteomic, June 1, 2006; 5(2): 144 - 153.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the American Association for Clinical Chemistry.