Clinical Chemistry
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Clinical Chemistry 31: 722-726, 1985;
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Clinical Chemistry, Vol 31, 722-726, Copyright © 1985 by American Association for Clinical Chemistry

Differences in cerebrospinal fluid proteins between patients with schizophrenia and normal persons

MG Harrington, CR Merril and EF Torrey

A survey of cerebrospinal fluid (CSF) proteins from normal persons and patients with schizophrenia reveals differences between the two populations. Computer-assisted densitometry of 68 proteins, resolved by two-dimensional electrophoresis and made visible by silver staining, shows six changes. Compared with their occurrence in the normal group, two proteins are increased in the schizophrenic patients by 22% and 27%, while four proteins are decreased by 29%, 46%, 20%, and 37% (p less than 0.005). Furthermore, two additional 40 000-Da proteins are found in CSF from 31.5% of the schizophrenic patients. Although these disease-associated proteins have not yet been found in 12 other neurological and psychiatric conditions, they have been found in patients with herpes simplex encephalitis (90%), Creutzfeldt-Jakob disease (67%), multiple sclerosis (13%), Parkinson's disease (12%), and a single case of Guillain-Barre syndrome. These two 40 000-Da proteins have never been found in CSF from any of 99 normal persons.


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 Brief Funct Genomic ProteomicHome page
R. G. Biringer, H. Amato, M. G. Harrington, A. N. Fonteh, J. N. Riggins, and A. F. R. Huhmer
Enhanced sequence coverage of proteins in human cerebrospinal fluid using multiple enzymatic digestion and linear ion trap LC-MS/MS
Brief Funct Genomic Proteomic, June 1, 2006; 5(2): 144 - 153.
[Abstract] [Full Text] [PDF]


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Copyright © 1985 by the American Association for Clinical Chemistry.