Clinical Chemistry
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Clinical Chemistry 31: 731-733, 1985;
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Clinical Chemistry, Vol 31, 731-733, Copyright © 1985 by American Association for Clinical Chemistry

Measurement of plasma fructosamine evaluated for monitoring diabetes

YS Lim and MJ Staley

The mean fructosamine concentration in plasma of diabetics (n = 200) differed significantly (p less than 0.001) from those of a hospitalized nondiabetic population (n = 163)--the latter mean being essentially the same for ambulatory subjects (n = 145), expectant mothers (n = 58), and patients with renal failure (n = 31), regardless of sex. In the diabetic group, values for plasma fructosamine correlated with those for glycated hemoglobin (r = 0.767, p less than 0.01) and glycated protein (r = 0.817, p less than 0.01). Values for plasma fructosamine were stable from day to day in patients with controlled blood glucose, but fluctuated in certain patients receiving only parenteral nutrition, even when their concentrations of glucose were normal and stable. We conclude that measurement of plasma fructosamine is suitable for assessing intermediate-term control of blood glucose when the turnover of plasma proteins is normal.


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Identification and Properties of Glycated Monoclonal IgA That Affect the Fructosamine Assay
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S. S. P. Gebhart, R. N. Wheaton, R. E. Mullins, and G. E. Austin
A Comparison of Home Glucose Monitoring With Determinations of Hemoglobin A1c, Total Glycated Hemoglobin, Fructosamine, and Random Serum Glucose in Diabetic Patients
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[Abstract] [PDF]


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Copyright © 1985 by the American Association for Clinical Chemistry.