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Clinical Chemistry 31: 757-762, 1985;
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Clinical Chemistry, Vol 31, 757-762, Copyright © 1985 by American Association for Clinical Chemistry

Two-dimensional proton nuclear magnetic resonance "maps" of acetaminophen metabolites in human urine

JR Bales, JK Nicholson and PJ Sadler

Two-dimensional proton-proton correlated NMR spectra of concentrated urine from a subject who had ingested a 1-g dose of acetaminophen are reported. These "maps" provide a considerable simplification of the spectrum in comparison with conventional one-dimensional NMR spectra. In the present case, peaks for all the major acetaminophen metabolites, including the L-cysteinyl conjugate, can be unambiguously assigned.





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Copyright © 1985 by the American Association for Clinical Chemistry.