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Clinical Chemistry 31: 822-825, 1985;
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Clinical Chemistry, Vol 31, 822-825, Copyright © 1985 by American Association for Clinical Chemistry

Routine "cardiac" and "hepatic" serum enzyme profiles in cardiac- transplant patients treated with cyclosporine A: operative and post- operative findings

FN McKenzie, GC Moses and AR Henderson

We report representative serum enzyme changes after cardiac transplantation in 20 patients receiving post-transplant therapy with cyclosporine. In general, the changes resembled those after acute myocardial infarction or coronary artery bypass surgery, but were more prolonged. Cardiac biopsy or episodes of cardiac rejection did not usually alter serum enzyme activities. Cyclosporine A toxicity appeared to be responsible for increases in serum transaminases (alanine and aspartate) and lactate dehydrogenase-5 activities. Serum gamma- glutamyltransferase activities were intermittently, and inexplicably, increased for months after the transplant.




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Copyright © 1985 by the American Association for Clinical Chemistry.