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Clinical Chemistry 31: 866-867, 1985;
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Clinical Chemistry, Vol 31, 866-867, Copyright © 1985 by American Association for Clinical Chemistry

Increased serum sulfate in pregnancy: relationship to gestational age

DE Cole, LS Baldwin and LJ Stirk

Controlled-flow ion chromatography has significantly improved the precision with which inorganic sulfate (SO4) can be measured in serum. In this study, we have shown that serum SO4 is increased in pregnancy. The increase appears to follow gestational age, resulting in a 39% higher value by the middle of the third trimester. We suggest that this increase is a natural physiological process, which enhances SO4 availability to the growing fetus and placenta.


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P. A. Dawson, L. Beck, and D. Markovich
Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene
PNAS, November 11, 2003; 100(23): 13704 - 13709.
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H. J. Lee, K. Sagawa, W. Shi, H. Murer, and M. E. Morris
Hormonal Regulation of Sodium/Sulfate Co-Transport in Renal Epithelial Cells
Experimental Biology and Medicine, October 1, 2000; 225(1): 49 - 57.
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Copyright © 1985 by the American Association for Clinical Chemistry.