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Clinical Chemistry 31: 868-870, 1985;
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Clinical Chemistry, Vol 31, 868-870, Copyright © 1985 by American Association for Clinical Chemistry

Use of dodecyl sulfate as an esterase inhibitor before gas- chromatographic determination of labile beta-adrenoceptor blocking drugs

G Holm, K Kylberg-Hanssen and L Svensson

Sodium dodecyl sulfate (SDS) was introduced as an esterase inhibitor in the determination of two extremely labile, ultrashort-acting beta- blockers-esmolol and flumolol--in whole blood. SDS was much more efficient than previously used agents in preventing hydrolysis. The assay comprises solvent extraction, perfluoroacylation, and capillary gas-chromatography with electron-capture detection. The limit of detection (the concentration at which the coefficient of variation is 10-15%) for the drugs is 5 nmol/L of whole blood.


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Copyright © 1985 by the American Association for Clinical Chemistry.