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Clinical Chemistry 31: 876-877, 1985;
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Clinical Chemistry, Vol 31, 876-877, Copyright © 1985 by American Association for Clinical Chemistry

Concentrations of protease and anti-protease in serum of patients with pancreatic cancer

PK Buamah and AW Skillen

We measured the concentrations of trypsin, elastase, and three anti- proteases-alpha 1-macroglobulin, alpha 1-antitrypsin, and alpha 1- antichymotrypsin-in serum from 10 patients with pancreatic carcinoma. All 10 showed increased elastase and decreased alpha 2-macroglobulin concentrations, nine had increased alpha 1-antichymotrypsin, and eight had increases in alpha 1-antitrypsin and trypsin. Serial studies during chemotherapy of one patient showed that the protease concentrations decreased during treatment but the concentrations of the anti-proteases remained abnormal.


The following articles in journals at HighWire Press have cited this article:


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J. M. Koomen, L. N. Shih, K. R. Coombes, D. Li, L.-c. Xiao, I. J. Fidler, J. L. Abbruzzese, and R. Kobayashi
Plasma Protein Profiling for Diagnosis of Pancreatic Cancer Reveals the Presence of Host Response Proteins
Clin. Cancer Res., February 1, 2005; 11(3): 1110 - 1118.
[Abstract] [Full Text] [PDF]


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Copyright © 1985 by the American Association for Clinical Chemistry.