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Clinical Chemistry 31: 1141-1143, 1985;
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Clinical Chemistry, Vol 31, 1141-1143, Copyright © 1985 by American Association for Clinical Chemistry

Effects of some anti-inflammatory drugs on 12 blood constituents: protocol for the study of in vivo effects of drugs

Z Jelic-Ivanovic, S Spasic, N Majkic-Singh and P Todorovic

We investigated the in vivo effects of acetylsalicylic acid, diclofenac, indomethacin, ibuprofen, and ketoprofen on the concentrations of various blood constituents. Total protein, glucose, calcium, and inorganic phosphate were not significantly affected by any of these drugs. Ketoprofen had no definite influence on any constituent. Acetylsalicylic acid induced an increase in cholesterol, triglyceride, and iron; albumin, uric acid, and creatinine decreased with ibuprofen therapy. Urea nitrogen increased in patients treated with diclofenac or indomethacin. Our protocol for the study of in vivo drug effects is discussed.


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Copyright © 1985 by the American Association for Clinical Chemistry.