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Clinical Chemistry 31: 1155-1157, 1985;
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Clinical Chemistry, Vol 31, 1155-1157, Copyright © 1985 by American Association for Clinical Chemistry

Liquid-chromatographic determination of chloride in sweat from cystic fibrosis patients and normal persons

DJ Pillion and E Meezan

Chloride concentrations in sweat were measured by "vacancy liquid chromatography," a technique in which anions eluting from an ion- exchange column in the presence of an elution buffer which absorbs at 280 nm cause a decrease in absorbance proportional to the concentration of the anion. Less than 1 microL of sweat suffices for this analysis, which takes 5 min per sample. Results were comparable to those obtained by conventional titrimetric determination of chloride. Sweat from cystic fibrosis patients had higher (104 +/- 26 mmol/L) chloride concentrations than sweat from normal persons (16 +/- 7 mmol/L). This technique can be used in the diagnosis of cystic fibrosis.




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Copyright © 1985 by the American Association for Clinical Chemistry.