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Clinical Chemistry 31: 1224-1226, 1985;
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Clinical Chemistry, Vol 31, 1224-1226, Copyright © 1985 by American Association for Clinical Chemistry

Paraproteinemia in patients with acquired immunodeficiency syndrome (AIDS) or lymphadenopathy syndrome (LAS)

K Heriot, AE Hallquist and RH Tomar

Eight of 15 patients with acquired immunodeficiency syndrome (AIDS) and six of nine patients with lymphadenopathy syndrome (LAS) had paraproteins in their sera. Twelve of these 14 were IgG kappa; the other two had no demonstrable light chains. The relationship of the paraprotein to the pathogenesis of AIDS is not clear, but we discuss its relation to derangements of B-cell immune regulation and function and to B-cell tumors in AIDS patients.


The following articles in journals at HighWire Press have cited this article:


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 CVIHome page
F. O. Seeborg, H. Gay, L. M. Schmiege III, D. Bernard, and W. T. Shearer
Immunoglobulin G({kappa}) [IgG({kappa})] and IgG({lambda}) Paraproteinemia in a Child with AIDS and Response to Highly Active Antiretroviral Therapy
Clin. Vaccine Immunol., November 1, 2005; 12(11): 1331 - 1333.
[Abstract] [Full Text] [PDF]

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 NEJMHome page
R. J. Konrad, L. J. Kricka, D. Goodman, J. Goldman, and L. Silberstein
Myeloma-Associated Paraprotein Directed against the HIV-1 p24 Antigen in an HIV-1-Seropositive Patient
N. Engl. J. Med., June 24, 1993; 328(25): 1817 - 1819.
[Full Text]


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