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Clinical Chemistry 31: 1329-1330, 1985;
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Clinical Chemistry, Vol 31, 1329-1330, Copyright © 1985 by American Association for Clinical Chemistry

Can potentially infectious specimens containing hepatitis B virus be identified on the basis of their biochemical profile?

L Burnett, SB Lowe, B Chan, JB Whitfield, BN Nightingale and WJ Hensley

The potential infectivity of 1129 randomly selected plasma specimens was directly assayed by hepatitis B virus (HBV) DNA dot-hybridization. Presence or absence of HBV was then correlated with a biochemical profile of 20 common analytes obtained on these same specimens. We found that potentially infectious specimens could not be identified on the basis of any combination of simple biochemical tests; indeed, the infectious specimens were more "normal" in some tests of liver function than were the non-infectious specimens.




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Copyright © 1985 by the American Association for Clinical Chemistry.