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Clinical Chemistry 31: 1358-1360, 1985;
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Clinical Chemistry, Vol 31, 1358-1360, Copyright © 1985 by American Association for Clinical Chemistry

Two radioassays for serum vitamin B12 and folate determination compared in a reference interval study

RH Christenson, GA Dent and A Tuszynski

For 154 subjects, we verified that vitamin B12 and folate status was normal, using as criteria the average polymorphonuclear lobe count, mean corpuscular volume, and hemoglobin concentration. We then used blood from these subjects to compare values obtained with two radioassay kits, each designed for simultaneous vitamin B12 and folate determination. Although regression analysis showed reasonable correlation between the folate (r = 0.87) and vitamin B12 (r = 0.94) kits, we observed significant differences in the overall mean values for vitamin B12 (p less than 0.01) and folate (p less than 0.001) as measured with the kits in this population. Radioassay standard-curve data for the folate assays were similar, but these data indicated greater sensitivity at low concentrations for one vitamin B12 kit than the other. Using reference intervals recommended in the kit inserts, we found that the vitamin B12 status for 9% of these subjects would have been misclassified by one kit, 2% by the other.


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Copyright © 1985 by the American Association for Clinical Chemistry.