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Clinical Chemistry 31: 1397-1399, 1985;
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Clinical Chemistry, Vol 31, 1397-1399, Copyright © 1985 by American Association for Clinical Chemistry

Electrophoresis of serum protein to detect alpha 1-antitrypsin deficiency: five illustrative cases

R Malfait, F Gorus and C Sevens

We describe five cases of severe alpha 1-antitrypsin (AAT) deficiency to illustrate the importance of visual inspection of electrophoretic patterns of serum proteins. In four patients the diagnosis of AAT deficiency was clinically unsuspected; in the other patient, the electrophoretic pattern was the first clue to confirm the diagnosis. Densitometric scanning of these patterns invariably overestimated the concentration of alpha 1-globulin. By visually inspecting electrophoretic strips instead of relying on densitometry, clinical chemists can help detect AAT deficiency earlier.




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Copyright © 1985 by the American Association for Clinical Chemistry.