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Clinical Chemistry 32: 169-171, 1986;
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Clinical Chemistry, Vol 32, 169-171, Copyright © 1986 by American Association for Clinical Chemistry

Photodiode array detection for liquid chromatographic profiling of carboxylic acids in physiological fluids: 3-hydroxy-3-methylglutaric aciduria

DN Buchanan and JG Thoene

3-Hydroxy-3-methylglutaric aciduria was detected in a newborn. The progress of the dietary therapy for the disorder was monitored by dual- column "high-performance" liquid chromatography with a computer- controlled photodiode array spectrophotometric detector. This procedure is a quick way to detect and monitor the progress of 3-hydroxy-3- methylglutaric aciduria.




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Copyright © 1986 by the American Association for Clinical Chemistry.