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Clinical Chemistry 32: 93-96, 1986;
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Clinical Chemistry, Vol 32, 93-96, Copyright © 1986 by American Association for Clinical Chemistry

Urinary excretion rates of 15 free steroids: potential utility in differential diagnosis of Cushing's syndrome

M Schoneshofer, B Weber, W Oelkers, K Nahoul and F Mantero

To evaluate their potential usefulness in the differential diagnosis of Cushing's syndrome, we estimated the urinary excretion rates of the following non-metabolized, unbound steroid hormones: pregnenolone, progesterone, 17-OH-pregnenolone, 17-OH-progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, dihydrotestosterone, 11-deoxycorticosterone, 11-deoxycortisol, corticosterone, cortisol, 18-OH-11-deoxycorticosterone, 18-OH- corticosterone, and aldosterone. These were measured in normal subjects and in patients with Cushing's disease, adrenal adenoma, or ectopic corticotropin syndrome. We used "high-performance" liquid chromatography and subsequent radioimmunoassay. Our results indicate that simultaneous estimation of urinary free cortisol and DHEA may be useful in differential diagnosis of hypercorticoid states due to adrenal adenoma and Cushing's disease.




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Copyright © 1986 by the American Association for Clinical Chemistry.