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Clinical Chemistry 32: 1942-1943, 1986;
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Clinical Chemistry, Vol 32, 1942-1943, Copyright © 1986 by American Association for Clinical Chemistry

Minimizing between-kit variability in immunoassay for carcinoembryonic antigen by use of a common standard

GC Zucchelli, A Pilo, MR Chiesa, S Masini and C Baccini

Between-laboratory agreement of CEA determinations collected in a multicenter study has been substantially improved (CV decreased from 60.4 to 21.6%) by converting the results from mass concentration units (ng/mL) of local kit standards to int. units/L of the international standard first IRP 73/601. Conversion factors for the kits most used were computed, during the same survey, from results of two analytical- recovery experiments in which control samples, supplemented with the international standard, were analyzed by participating laboratories (n = 96).




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Copyright © 1986 by the American Association for Clinical Chemistry.