Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 32: 2160-2165, 1986;
This Article
Right arrow Order Full text via Infotrieve
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ranby, M.
Right arrow Articles by Bucht, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ranby, M.
Right arrow Articles by Bucht, G.

Clinical Chemistry, Vol 32, 2160-2165, Copyright © 1986 by American Association for Clinical Chemistry

Age dependence of tissue plasminogen activator concentrations in plasma, as studied by an improved enzyme-linked immunosorbent assay

M Ranby, N Bergsdorf, T Nilsson, G Mellbring, B Winblad and G Bucht

A procedure for improving the specificity of enzyme-linked immunosorbent assays (ELISA) was devised, based on addition of antigen- specific or non-immune immunoglobulins to the citrated plasma sample and defining the difference in assay response between these two mixtures as the antigen-specific part of the response. When applied to measurement of tissue plasminogen activator (t-PA; EC 3.4.21.31) antigen in plasma, this procedure resulted in elimination of the overestimates obtained in a large proportion (10-20%) of patients' samples when assayed according to the conventional ELISA technique. Basal t-PA concentrations in plasma were found to be highly age- dependent, normal values being about 3 micrograms/L for adults near 30 years of age and about 10 micrograms/L for those over 60. Patients with gallbladder stone disease had increased mass concentrations of t-PA in plasma, even when corrected for the age effect; patients with multi- infarct dementia did not.


The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
R. Rej
Clinical Chemistry through Clinical Chemistry: A Journal Timeline
Clin. Chem., December 1, 2004; 50(12): 2415 - 2458.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
W. M. R. Broekmans, I. A. A. Klopping-Ketelaars, J. A. Weststrate, L. B. M. Tijburg, G. van Poppel, A. A. Vink, T. T.J.M Berendschot, M. L. Bots, W. A. M. Castenmiller, and A. F. M. Kardinaal
Decreased Carotenoid Concentrations Due to Dietary Sucrose Polyesters Do Not Affect Possible Markers of Disease Risk in Humans
J. Nutr., March 1, 2003; 133(3): 720 - 726.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. A. Poli, G. H. Tofler, M. G. Larson, J. C. Evans, P. A. Sutherland, I. Lipinska, M. A. Mittleman, J. E. Muller, R. B. D’Agostino, P. W. F. Wilson, et al.
Association of Blood Pressure With Fibrinolytic Potential in the Framingham Offspring Population
Circulation, January 25, 2000; 101(3): 264 - 269.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
J. B. Meigs, M. A. Mittleman, D. M. Nathan, G. H. Tofler, D. E. Singer, P. M. Murphy-Sheehy, I. Lipinska, R. B. D'Agostino, and P. W. F. Wilson
Hyperinsulinemia, Hyperglycemia, and Impaired Hemostasis: The Framingham Offspring Study
JAMA, January 12, 2000; 283(2): 221 - 228.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
W. L. Chandler, M. L. Jascur, and P. J. Henderson
Measurement of Different Forms of Tissue Plasminogen Activator in Plasma
Clin. Chem., January 1, 2000; 46(1): 38 - 46.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
L. Johansson, J.-H. Jansson, K. Boman, T. K. Nilsson, B. Stegmayr, and G. Hallmans
Tissue Plasminogen Activator, Plasminogen Activator Inhibitor-1, and Tissue Plasminogen Activator/Plasminogen Activator Inhibitor-1 Complex as Risk Factors for the Development of a First Stroke
Stroke, January 1, 2000; 31(1): 26 - 32.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
B. Kristensen, J. Malm, T. K. Nilsson, J. Hultdin, B. Carlberg, G. Dahlen, and T. Olsson
Hyperhomocysteinemia and Hypofibrinolysis in Young Adults With Ischemic Stroke
Stroke, May 1, 1999; 30(5): 974 - 980.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
R. F. Macko, S. J. Kittner, A. Epstein, D. K. Cox, M. A. Wozniak, R. J. Wityk, B. J. Stern, M. A. Sloan, R. Sherwin, T. R. Price, et al.
Elevated Tissue Plasminogen Activator Antigen and Stroke Risk : The Stroke Prevention in Young Women Study
Stroke, January 1, 1999; 30(1): 7 - 11.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. M. Thogersen, J.-H. Jansson, K. Boman, T. K. Nilsson, L. Weinehall, F. Huhtasaari, and G. Hallmans
High Plasminogen Activator Inhibitor and Tissue Plasminogen Activator Levels in Plasma Precede a First Acute Myocardial Infarction in Both Men and Women : Evidence for the Fibrinolytic System as an Independent Primary Risk Factor
Circulation, November 24, 1998; 98(21): 2241 - 2247.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
B. Kristensen, J. Malm, T. K. Nilsson, J. Hultdin, B. Carlberg, and T. Olsson
Increased Fibrinogen Levels and Acquired Hypofibrinolysis in Young Adults With Ischemic Stroke
Stroke, November 1, 1998; 29(11): 2261 - 2267.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
O C E Gebara, M A Mittleman, B W Walsh, I Lipinska, F K Welty, G Bellotti, J E Muller, F K Sacks, and G H Tofler
Fibrinolytic potential is significantly increased by oestrogen treatment in postmenopausal women with mild dyslipidaemia
Heart, September 1, 1998; 80(3): 235 - 239.
[Abstract] [Full Text]

Home page
 J CARDIOVASC PHARMACOL THERHome page
Y. Uehara, N. Hirawa, A. Numabe, Y. Kawabata, H. Nagoshi, H. Negoro, S. Fujiwara, T. Gomi, T. Ikeda, A. Goto, et al.
Angiotensin-Converting Enzyme Inhibition Delays Onset of Glucosuria With Regression of Renal Injuries in Genetic Rat Model of Non-Insulin-Dependent Diabetes Mellitus
Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1998; 3(4): 327 - 335.
[Abstract] [PDF]

Home page
 CirculationHome page
J.-H. Jansson, K. Boman, M. Brannstrom, and T. K. Nilsson
High Concentration of Thrombomodulin in Plasma Is Associated With Hemorrhage : A Prospective Study in Patients Receiving Long-term Anticoagulant Treatment
Circulation, November 4, 1997; 96(9): 2938 - 2943.
[Abstract] [Full Text]

Home page
 CirculationHome page
J. G. van der Bom, P. de Knijff, F. Haverkate, M. L. Bots, P. Meijer, P. T. V. M. de Jong, A. Hofman, C. Kluft, and D. E. Grobbee
Tissue Plasminogen Activator and Risk of Myocardial Infarction: The Rotterdam Study
Circulation, June 17, 1997; 95(12): 2623 - 2627.
[Abstract] [Full Text]

Home page
 CirculationHome page
F. K. Welty, M. A. Mittleman, P. W.F. Wilson, P. A. Sutherland, T. H. Matheney, I. Lipinska, J. E. Muller, D. Levy, and G. H. Tofler
Hypobetalipoproteinemia Is Associated With Low Levels of Hemostatic Risk Factors in the Framingham Offspring Population
Circulation, February 18, 1997; 95(4): 825 - 830.
[Abstract] [Full Text]

Home page
 CirculationHome page
O. C. E. Gebara, M. A. Mittleman, P. Sutherland, I. Lipinska, T. Matheney, P. Xu, F. K. Welty, P. W. F. Wilson, D. Levy, J. E. Muller, et al.
Association Between Increased Estrogen Status and Increased Fibrinolytic Potential in the Framingham Offspring Study
Circulation, April 1, 1995; 91(7): 1952 - 1958.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American Association for Clinical Chemistry.