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Clinical Chemistry 32: 333-336, 1986;
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Clinical Chemistry, Vol 32, 333-336, Copyright © 1986 by American Association for Clinical Chemistry

A possible etiological role for ascorbate in calculi formation

AH Chalmers, DM Cowley and JM Brown

Studies of recurrent stone formers indicated that they have significantly increased urinary oxalate and decreased ascorbate excretions. Results of oral and intravenous administration of ascorbate indicate an enhanced production of oxalate from ascorbate in recurrent calcium stone formers as compared with normal persons and that most of this oxalate is generated in the gut.


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Copyright © 1986 by the American Association for Clinical Chemistry.