Clinical Chemistry, Vol 32, 346-348, Copyright © 1986 by American Association for Clinical Chemistry

Change in concentrations of myogenic components of serum during 93 h of strenuous physical exercise

H Kosano, T Kinoshita, N Nagata, O Takatani, M Isobe and Y Yazaki

Effects of 93 h of long, strenuous ranger training on activities of creatine kinase (CK) and lactate dehydrogenase (LD), along with their isoenzymes, and on concentration of myosin light chain were examined in sera of young soldiers. Total CK activity in serum was measured before, during, and after the training. Throughout, total CK activity in serum increased steadily. At the end of the training, activity of CK-MB was increased but its activity ratio to total CK remained unchanged; the activity ratio of LD1/LD2 also was not increased, although total LD activity was increased. Myosin light chain was increased by about fourfold at the end of the training and remained high for three days thereafter. However, its concentration was much lower than in myopathies such as polymyositis and Duchenne muscle dystrophy. The increased activities in serum of total CK and CK-MB isoenzyme on strenuous physical exercise evidently were of noncardiac origin. Although CK activity was comparable with that seen in myopathies accompanied by disintegration of skeletal muscle, the relatively low concentration of myosin light chain in serum suggests minimal skeletal muscle damage.

The following articles in journals at HighWire Press have cited this article:

				M. Lofberg, R. Tahtela, M. Harkonen, and H. Somer Myosin Heavy-Chain Fragments and Cardiac Troponins in the Serum in Rhabdomyolysis: Diagnostic Specificity of New Biochemical Markers Arch Neurol, December 1, 1995; 52(12): 1210 - 1214. [Abstract] [PDF]