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Clinical Chemistry 32: 425-428, 1986;
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Clinical Chemistry, Vol 32, 425-428, Copyright © 1986 by American Association for Clinical Chemistry

Degree of unsaturation of the fatty acid chains of phospholipids influences the fluorescence polarization: implications for evaluating fetal lung maturity

JC Dohnal, LJ Bowie and HJ Burstein

To study the effect of fatty acid chain saturation on the fluorescence polarization assay as a measure of fetal lung maturity, we used purified phospholipids isolated from human amniotic fluid and various commercial phospholipids. We found that the fluorescence polarization value decreased as the concentration of unsaturated fatty acids increased. In contrast, the lecithin/sphingomyelin ratio increases with increasing amounts of saturated lecithin, produced as the fetal lung matures. Since only saturated lecithins are surface active, the two indices of fetal respiratory status must reflect different properties of lung surfactant.




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Copyright © 1986 by the American Association for Clinical Chemistry.