Clinical Chemistry
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Clinical Chemistry 32: 505-507, 1986;
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Clinical Chemistry, Vol 32, 505-507, Copyright © 1986 by American Association for Clinical Chemistry

Evaluation of a new dynamic viscometer for measuring the viscosity of whole blood and plasma

WL Chandler and G Schmer

We evaluated a new type of dynamic viscometer, the Sonoclot Coagulation Analyzer, for use in measuring the viscosity of whole-blood and plasma. Such information can be useful in monitoring patients with hyperviscosity syndromes, e.g., from multiple myeloma. A vibrating Teflon or plastic probe continuously measures dynamic viscosity. The instrument can be calibrated to measure a range of viscosities from 0.69 to 23 cP (mN X s X m-2) or more. The coefficient of variation at 0.69 cP was 3-4% for measurements with the Teflon probe, 7-9% with the plastic probe. Viscosity measured at 37 degrees C for plasma and whole- blood samples from 20 normal patients was 1.22 (SD 0.05) cP and 3.63 (SD 0.52) cP, respectively. Dynamic viscosity measured in blood samples from a single source, with contrived hematocrits ranging from 0 to 89%, increased exponentially as a function of hematocrit, confirming previous studies. Overall, we found this instrument simple and quick to operate, producing accurate, precise viscosity measurements over at least a 40-fold range of viscosity.


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 Anesth. Analg.Home page
C. Konrad, T. Markl, G. Schuepfer, H. Gerber, and M. Tschopp
The Effects of In Vitro Hemodilution with Gelatin, Hydroxyethyl Starch, and Lactated Ringer’s Solution on Markers of Coagulation: An Analysis Using SONOCLOTTM
Anesth. Analg., March 1, 1999; 88(3): 483 - 483.
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Copyright © 1986 by the American Association for Clinical Chemistry.