Clinical Chemistry
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Clinical Chemistry 32: 536-538, 1986;
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Clinical Chemistry, Vol 32, 536-538, Copyright © 1986 by American Association for Clinical Chemistry

Mass-spectrometric determination of serum cortisol: comparison of data from two independent laboratories

SJ Gaskell and L Sieckmann

Isotope dilution and mass spectrometry were used in two independent laboratories to determine cortisol in 15 plasma and serum pools used in the British and German national schemes for the external quality assessment of routine assays. For the concentration range 240-700 nmol/L, differences between the data obtained by the two laboratories were generally less than 4% but were approximately 7% in two instances. The discrepancies are nevertheless small in comparison with the bias observed for many routine assays.




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Copyright © 1986 by the American Association for Clinical Chemistry.